Central cholinergic neuronal degeneration promotes the development of postoperative cognitive dysfunction

P147: Postoperative Cognitive Dysfunction and Neuroinflammation Associated with Cardiac Surgery

One of the incapacitating postoperative morbidities that was seen in all types of surgery is Postoperative cognitive dysfunction (POCD). The elder patients and also cardiac surgery patients (CSPs) are at particular risk. Additionally it was shown that the severity, extension of impairment and the incidence rate of POCD is more in CSPs. POCD is a dementia-like symptoms disorder is characterized ...

Neuronal degeneration and mitochondrial dysfunction.

Postoperative Cognitive Dysfunction

Cardiac surgery, and especially cardiopulmonary bypass (CPB), has been the poster child for postoperative cognitive morbidity. Over the past 10-15 years, however, it has become increasingly clear that disruption or decline in cognitive function is also fairly widespread among elderly non-cardiac surgical patients. The reasons are a matter of considerable controversy and this brief overview will...

Postoperative cognitive dysfunction.

Postoperative cognitive dysfunction is a severe and life-threatening complication after an operation. The mobilisation of the patient is difficult and, therefore, the stay of the patient in the hospital is extended and the resulting immobilisation is associated with further complications (e.g. decubitus, pneumonia, or thrombosis). The genesis of the postoperative cognitive dysfunction has diffe...

Postoperative cognitive dysfunction

Postoperative cognitive dysfunction (POCD) refers to a deterioration in cognition noted to occur after surgery and anesthesia. Recent studies have demonstrated a number of correlates and risk factors for this condition, although much remains to be elucidated in terms of the true incidence, etiology, prevention, and treatment.